Non-coding RNAs as Modulators for Drug Delivery and Epigenetic Changes in Immunotherapy Resistancy of Cancer

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Cancer
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is considered a multifactorial disease
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that arisen
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arisen
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arises
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from an alternative function of epigenetic modulations and genetic factors. A wide spectrum of strong evidence research has shown that non-coding RNAs (
ncRNAs
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) are related to the epigenetic modulation of
cancer
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genes and their associated networks. A paramount consideration of molecular epigenetic mechanism is the expression of
ncRNAs
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making a more significant contribution to the regulation of
cancer
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pathogenesis and many other diseases.
However
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,
cancer
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immunotherapy
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is a well-established method for the treatment of a wide range of
cancer
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types, the root of the problem lies in the different
responses
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in patients and low-level
responses
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or tumour cells evading the immune functions. With many tumours resentencing to
immunotherapy
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in
cancer
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diseases,
ncRNAs
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play an unprecedented role in enhancing the efficiency of
immunotherapy
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towards tumours through epigenetic changes. In
this
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review, we will look back over current knowledge of the functions, expressions, critical mechanisms and drug delivery of
ncRNAs
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via epigenetic modulations.
This
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review will bring great benefits to novel ncRNA-based immune classes in
cancer
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immunotherapy
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.
Finally
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, the ultimate purpose of
this
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study is to arouse interested researchers to conduct on the theory because of a large knowledge gap in ncRNA-based
cancer
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immunotherapy
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for
responses
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to treatment.
However
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, not only have a few epigenetic drugs been approved by FDA, but
also
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a new hope has dawned on RNA-based therapeutics with epigenetic effects for
cancer
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treatment. They potentially have a driving force in
cancer
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immunotherapy
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without side effects.
In addition
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, Other molecular mediated RNA means combined with nanoparticles, Crispr/Cas9, polymer-based, lipid-based nanoparticles (LBNPs) can enhance RNA delivery to the tumours, tissues and immune cells. They can promote immune
responses
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by either silencing or upregulating the immune-relevant genes to improve the efficiency of new drug delivery to cross-cell membranes. To conclude, now a more nuanced understanding of
this
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research could pave the way for a new propelling investigation. We hope that it will be given the scientists an appreciation of some of the issues involved. The bottom line is that the future prospects of the research on personalized medicine would shed light on novel ncRNA-based
cancer
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immunotherapy
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with epigenetics changes.

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