A normal
human’sChange noun form
show examples
body
has 206 bones
inChange preposition
show examples
different sizes and shapes holding the other organs and
tissues
together. Intrinsically, bones can repair themselves during a specific time period[1].
However
, in some cases due to
bone
diseases
such
as osteoporosis, osteomyelitis, malignant
tumorsChange the spelling
show examples
, or traumatic accidents, the process of healing may not occur or gets lengthy[2]. One of the most common
bone
diseases that can cause severe
bone
loss and infections is
bone
cancer
. Despite the development of medical sciences,
cancer
is still a threatening health issue. Surgery, chemotherapy, and radiotherapy are common methods for treating
cancer
[3]. These treatments have some drawbacks that could be harmful and endanger healthy
tissues
and
cells
;
for example
, weakening the immune system of a patient’s
body
because of the exceeding amount of
drugFix the agreement mistake
show examples
or undesirable release of
drugFix the agreement mistake
show examples
in chemotherapy and causing large
bone
defects after removing
tumorsChange the spelling
show examples
in surgery[3].
Besides
, completely removing the
tumorChange the spelling
show examples
may not occur,
subsequently
, residual
cancer
cells
surrounding the healthy
tissues
trigger
tumorChange the spelling
show examples
recurrence1. In recent years, investigations have shown that
heat
can kill human
body
cells
including
cancer
cells
which are more sensitive to
heat
than healthy
cells
[4]. Utilizing
heat
to eliminate or diminish
tumorsChange the spelling
show examples
is called hyperthermia treatment. Commonly, there are several approaches to
generateWrong verb form
show examples
heat
within the
body
such
as using magnetic particles [4]. There is another approach to
eradicateWrong verb form
show examples
tumorsChange the spelling
show examples
by
heat
which is done by
photothermalAdd an article
the photothermal
a photothermal
show examples
phenomenon
that is
rooted in the interaction of the material with light, so it depends on the optical properties of the material[5]. Photothermal therapy (PTT) has certain advantages over other methods,
such
as high selectivity, minimal invasiveness, and no systemic effects[6]. These privileges have turned PTT
toChange preposition
show examples
an attractive means of tackling
cancer
,
therefore
, many researchers have studied
on Change preposition
show examples
certain materials with the ability
of convertingReplace the preposition
show examples
light into
heat
. Metallic particles with diverse shapes, carbon-based nanoparticles, semiconductors, and organic compounds are
such
substances[5]. In the
last
decade, many researchers have spent their effort
to obtainChange the verb form
show examples
a series of
materialFix the agreement mistake
show examples
that not only do have the ability to remove
tumorsChange the spelling
show examples
through PTT but
also
possess different biological properties in order to reduce
risksCorrect article usage
show examples
of their use. A group of
glasses
called ‘bioglass’ which were
first
introduced by L. Hench in the 1970s [7]
,Remove the comma
show examples
are known for their intrinsic ability of bonding with
boneAdd an article
show examples
throughChange preposition
show examples
forming a hydroxyapatite-like layer on their surface when
exposingWrong verb form
show examples
to biological fluids.
This
means bioactive
glasses
can regenerate
the Correct article usage
show examples
damaged or lost tissue, alongside their
marvelousChange the spelling
show examples
optical features. To reap the benefits of
biologicalCorrect article usage
show examples
and optical properties of these distinguished
glasses
simultaneously, numerous studies have been conducted. In one of these, Wang et al. introduced a bismuth-doped phosphosilicate glass that could invert the growth of a type of rat
cells
through photothermal therapy and were
also
able to regenerate the damaged
bone
tissue2. In another research, a sol-gel bioactive glass containing 5%molar manganese
wereCorrect subject-verb agreement
show examples
loaded with chlorin e6 to combine photodynamic and photothermal therapies by irradiating the sample with 660nm and 808nm laser, respectively, for
treatmentCorrect article usage
show examples
of tumorous
bone
defects3. Ironically, manganese is a trace element that has proven to be a great agent in the growth of hard
tissues
by promoting osteogenic reactions and greatly affecting
bone
regeneration due to increasing osteoblast response and cell adhesion and proliferation11-16. In
this
regard, bioactive
glasses
have been determined as promising agents for delivering and sustained release of therapeutic ions in the
body
fluids microenvironment due to their biodegradability.