Do contaminants cause pollution? To what extent do you agree?

Contaminants in the atmosphere appear to have harmful effects on
neurodevelopment
and cognitive function. When Lilian Calderón-Garcidueñas discovered abundant hallmarks of Alzheimer’s disease in a batch of human brain samples a few years ago, she
initially
wasn’t sure what to make of it. The University of Montana
neuropathologist
had been studying the brains as part of her research on environmental effects on neural development, and
this
particular set of samples came from autopsy examinations carried out on people who had died suddenly in Mexico City, where she used to work as a researcher and physician.
Although
Calderón-Garcidueñas had collected much of the tissue herself while attending the autopsies in Mexico, the light-microscope slides she was
analyzing
consider in detail and subject to an analysis in order to discover essential features or meaning
analysing
had been prepared by her colleagues, so she was in the dark about what patient each sample came from. By the end of the project, she’d identified accumulations of the Alzheimer’s disease–associated proteins amyloid-ß and hyperphosphorylated tau in almost all of the 203 brains she studied. “When I started opening envelopes to see who [each sample] belonged to
.
Accept space
.
. . I was devastated,” she says. The people whose brains she’d been studying were not only adults, but teens and even children. The youngest was 11 months old. “My
first
thought was, ‘What am I going to do with
this
? What am I going to tell people?’”
she
Suggestion
She
says. “I was not expecting
such
a devastating, extreme pathology.” Despite her shock, Calderón-Garcidueñas had a reason to be on the lookout for signs of a disease usually associated with the elderly in these samples. For the
last
three decades, she’d been studying the health effects of Mexico City’s notoriously polluted air—a blight that earned the capital the dubious distinction of most polluted
megacity
on the planet from the United Nations in 1992. During that time, she’s discovered many links between exposure to air pollution and signs of neural damage in animals and humans.
Although
her findings are observational, and the pathology of proteins
such
as amyloid-ß is not fully understood, Calderón-Garcidueñas argues that air pollution is the most likely culprit behind the development of the abnormalities she saw in her postmortem samples—plus many other detrimental changes to the brains of Mexico City’s residents.

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    • Sentence 2 - Detailed background statement
    • Sentence 3 - Thesis
    • Sentence 4 - Outline sentence
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    • Sentence 1 - Topic sentence
    • Sentence 2 - Example
    • Sentence 3 - Discussion
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    • Sentence 1 - Topic sentence
    • Sentence 2 - Example
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