It is clear that a wide spectrum of human
diseases
is a function of
epigenome
modulation. Environmental factors and lifestyle particularly nutrition can modify the regulation of the
epigenome
.
Bioactive
peptides
(BAPs)
Add a missing verb
show examples
drivingReplace the word
show examples
fromChange preposition
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different
sources
such
as
food
sources
, animal
sources
, vegetal
sources
, and exogenous
sources
. They affect
epigenome
regulation through undergoing changes
ofChange preposition
show examples
DNA methylation, histone acetylation, non-coding RNAs, and miRNAs.
Bioactive derivedAdd a hyphen
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food
peptides
with epigenetic
effects
can be a contributing factor in different medical conditions
such
as cancer, cardiovascular
diseases
(
CVDs
), neurological and
neurodegenerative
disorders
, chronic obstructive pulmonary disease (COPD), and type 2 diabetes (T2DM).
In the present chapter, we have covered the function epigenetics process, different types of epigenetic
diseases
,
providingWrong verb form
show examples
various information
ofChange preposition
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BAPs, collected the variety of
bioactive
derived
food
peptides
with
epigenome
effects
,
prevention
and
treatment
of chronic
diseases
including cancer,
CVDs
, neurological and
neurodegenerative
disorders
diseases
, and T2DM by
bioactive
food
peptides
with epigenetic
effects
, the
last
but not the least is epigenetic therapy by
bioactive
food
peptides
. The study set out to clarify the role of
bioactive
food
peptides
forChange preposition
show examples
the
prevention
and
treatment
of chronic
diseases
through modulation of the
Epigenome
.
Bioactive
food
peptides
with epigenetic
effects
for instance
Lunasin, BCM7(Beta-casomorphin-7), and GM7 (Gliadinomorphin-7) are defined as
epigenome
modifiers
toChange preposition
show examples
treatmentAdd an article
show examples
of chronic
diseases
.
Finally
, in
this
chapter, the results fueled our view that Lunasin is considered an anticancer peptide and as a clinical trial for
treatmentAdd an article
show examples
of neurological and
neurodegenerative
disorders
.
Accordingly
, in the near future, Lunasin will lay the groundwork for therapeutics and
prevention
of chronic
diseases
especially
neurodegenerative
disorders
,
CVDs
, and cancer with fewer side
effects
.
Although
,Remove the comma
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BCM7 have positive
effects
on
neurodegenerative
disorders
, there is not enough a large scale of groundbreaking projects
whetherChange preposition
show examples
it can impact on
treatmentAdd an article
show examples
of
CVDs
or not, depside contrasting findings. It will be a great challenge to come up with a definitive answer to
this
question in the future.
Lastly
, there is not enough evidence on the
effects
of GM7
toChange preposition
show examples
treatmentCorrect article usage
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and
prevention
of chronic disease.
However
, only a few epigenetic drugs have currently been approved by the FDA, a new hope dawned on
bioactive
food
peptides
with epigenetic
effects
would be
as Change preposition
show examples
a driving force to
prevention
and
treatment
of chronic
diseases
without any side
effects
by the different molecular effective means like Nano delivery or Si-RNA, and so on.
Additionally
, despite a large knowledge gap,
bioactive
food
peptides
with epigenetic
effects
have a large impact on health so
as that Correct word choice
show examples
there is a demand for more attention to be paid to the development of peptide therapeutics and follow-up studies. They will make a considerable contribution to ideal therapeutic candidates for chronic
diseases
through epigenomic modulation soon. To conclude, by
this
study, now a more nuanced understanding of
bioactive
food
peptides
with epigenetic
effects
would pave the way for new propelling investigation.