Role of Epigenetics in Human Diseases: Bioactive Food Peptides for the Prevention and Treatment of Chronic Diseases through Modulation of the Epigenome

It is clear that a wide spectrum of human
diseases
is a function of
epigenome
modulation. Environmental factors and lifestyle particularly nutrition can modify the regulation of the
epigenome
.
Bioactive
peptides
(BAPs)
Add a missing verb
are driving
show examples
driving
Replace the word
drive
show examples
from
Change preposition
by
show examples
different
sources
such
as
food
sources
, animal
sources
, vegetal
sources
, and exogenous
sources
. They affect
epigenome
regulation through undergoing changes
of
Change preposition
in
show examples
DNA methylation, histone acetylation, non-coding RNAs, and miRNAs.
Bioactive derived
Add a hyphen
Bioactive-derived
show examples
food
peptides
with epigenetic
effects
can be a contributing factor in different medical conditions
such
as cancer, cardiovascular
diseases
(
CVDs
), neurological and
neurodegenerative
disorders
, chronic obstructive pulmonary disease (COPD), and type 2 diabetes (T2DM). In the present chapter, we have covered the function epigenetics process, different types of epigenetic
diseases
,
providing
Wrong verb form
provided
show examples
various information
of
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on
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BAPs, collected the variety of
bioactive
derived
food
peptides
with
epigenome
effects
,
prevention
and
treatment
of chronic
diseases
including cancer,
CVDs
, neurological and
neurodegenerative
disorders
diseases
, and T2DM by
bioactive
food
peptides
with epigenetic
effects
, the
last
but not the least is epigenetic therapy by
bioactive
food
peptides
. The study set out to clarify the role of
bioactive
food
peptides
for
Change preposition
in
show examples
the
prevention
and
treatment
of chronic
diseases
through modulation of the
Epigenome
.
Bioactive
food
peptides
with epigenetic
effects
for instance
Lunasin, BCM7(Beta-casomorphin-7), and GM7 (Gliadinomorphin-7) are defined as
epigenome
modifiers
to
Change preposition
for
show examples
treatment
Add an article
the treatment
show examples
of chronic
diseases
.
Finally
, in
this
chapter, the results fueled our view that Lunasin is considered an anticancer peptide and as a clinical trial for
treatment
Add an article
the treatment
show examples
of neurological and
neurodegenerative
disorders
.
Accordingly
, in the near future, Lunasin will lay the groundwork for therapeutics and
prevention
of chronic
diseases
especially
neurodegenerative
disorders
,
CVDs
, and cancer with fewer side
effects
.
Although
,
Remove the comma
apply
show examples
BCM7 have positive
effects
on
neurodegenerative
disorders
, there is not enough a large scale of groundbreaking projects
whether
Change preposition
on whether
show examples
it can impact on
treatment
Add an article
the treatment
show examples
of
CVDs
or not, depside contrasting findings. It will be a great challenge to come up with a definitive answer to
this
question in the future.
Lastly
, there is not enough evidence on the
effects
of GM7
to
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on
show examples
treatment
Correct article usage
the treatment
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and
prevention
of chronic disease.
However
, only a few epigenetic drugs have currently been approved by the FDA, a new hope dawned on
bioactive
food
peptides
with epigenetic
effects
would be
as
Change preposition
apply
show examples
a driving force to
prevention
and
treatment
of chronic
diseases
without any side
effects
by the different molecular effective means like Nano delivery or Si-RNA, and so on.
Additionally
, despite a large knowledge gap,
bioactive
food
peptides
with epigenetic
effects
have a large impact on health so
as that
Correct word choice
apply
show examples
there is a demand for more attention to be paid to the development of peptide therapeutics and follow-up studies. They will make a considerable contribution to ideal therapeutic candidates for chronic
diseases
through epigenomic modulation soon. To conclude, by
this
study, now a more nuanced understanding of
bioactive
food
peptides
with epigenetic
effects
would pave the way for new propelling investigation.
Submitted by farnooshaliazami on

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