IELTS Writing Samples Band 0.5

Want to improve your IELTS score? Get instant feedback and learn from your mistakes!
In essence, the authors note that the loss of AR in LebRb neurons left body mass, glucose, and puberty much the same but aided fertility. The mice had more regular cycles and healthier ovaries, and the authors wrote that this recovery likely came after birth, when AR signals fell silent. Losing these signals blunted some effects of prenatal androgen exposure. So, the study shows that AR in LepRb cells ties excess androgen to the loss of cycles, and that the neural circuits for puberty and for female cyclicity lie apart in the brain.
Earlier work had shown that when androgens rise above normal levels, fertility is often unsettled. Studies in animals show that early exposure to dihydrotestosterone (DHT) had lasting effects on both reproduction and metabolism. Androgen receptors appear to sit at the center of this effect, but their exact role is still not clear. From there, the authors thought that some hypothalamic LepRb neurons with these receptors could link androgen excess to the reproductive problems seen in females.
Crisapride might block the HERG potassium channel, as the authors proposed. The team wanted to find out why a gut motility drug had raised concern in clinical records of long-Q-T syndrome, torsades de pointes, and even deaths. At the time, the cellular mechanism wasn’t yet clear, but studies on rabbit Purkinje fibers had shown that crisapride could prolong the cardiac action potential and trigger early after-depolarization. Together, this work pointed to the HERG potassium channel as the likely site of action behind the drug’s cardiac effect.
In recent years, a significant debate has emerged regarding whether the government should invest in public services or allocate funds on arts. Proponents of the first view argue that spending on public services such as healthcare, education and infrastructure plays a crucial role in improving quality of life, thereby enhancing living standards. While I acknowledge these benefits, I only partly agree with this viewpoint, as I firmly believe that supporting artistic fields like music and painting is equally vital for preserving cultural heritage and promoting mental well-being.
4.The authors conclude that the β1-AR has a clear role in cardiac output. When this receptor is absent, the heart loses its normal chronotropic and inotropic responses, and many mice do not survive. As they note “in this model, β2-AR plays only a minor part in heart’s response to catecholamines.” Notably, both receptors are linked to Gs proteins and activate adenylate cyclase, but their roles are not the same, each subtype has its own purpose, as stated. They also added at the end that this model is a source on cardiovascular changes in disease.
Rohrer and colleagues noted that each β - adrenergic receptor (β-AR) subtype is necessary for development and cardiac function. Their idea comes from the limits of drugs selectivity, since different receptors are found in the same tissues, so it is hard to tell each role apart. Even with this, β-AR agonists are known to raise heart rate and contractility, there is still a doubt about the subtype behind this effect. Some studies saw both β1-and β2-ARs in the response, others mainly tied to β1- AR.
Noise aversion in dogs often begins quietly, almost unnoticed, a flinch at a sound, a heartbeat that races before the thunder arrives. To many owners it seems trivial at first, but for the dog, it is real and consuming. Among the options now available for managing fear-based behavior in dogs.
In recent years, a significant debate has emerged over whether higher education should be free or payments-based. Advocates of the first view argue that free education plays a crucial role in fostering social equality and increasing labour force, while opponents claim that tuition fees allow universities to expand facilities and organise events. This essay will discuss both perspectives and present my personal viewpoint.
The authors acknowledge that their work focuses solely on the isolated kinase domain rather than the full-length receptor, which may fail to consider subtle functional layers arising from juxtamembrane and transmembrane regions, as noted by McLaughlin et al. (2005) and Moriki et al. (2001). They observe that crystallization offers a static view of an inherently flexible system. As the authors note, “the two regions are not present in the crystal structures,” leaving open the possibility that the kinase domains might interact in a more fluid manner to activate one another.
The authors conclude that conserved residues across EGFR family members drive a shared activation mechanism. Sequence alignment reveals that HER2 and HER4, like EGFR, are autoinhibited and activated though the same asymmetric dimeric configuration, while ErbB3, lacking catalytic activity, likely functions as cyclin-like activator for its relatives. Structurally, their crystallographic findings show that this activation mirrors the CDK-cyclin mechanism, where dimerization relieves inhibition to restore catalytic function. Overall, the study defines a coherent model that sets out how EGFR and its homologues adopt an intrinsic allosteric switch to control activation, each effectively serving as its own “cyclin.”
The hypothesis aimed to reveal how β2AR and its Gs protein move through shifting conformations. As the authors put it,” we sought to visualize by cryo-EM the transition of conformational ensembles”. Their rationale was to bridge a gap in structural studies and, above all, to capture fleeting intermediates along this pathway. They argued that such insight could guide more rational pharmacology, “To outline the conformational landscape, to understand G– protein selectivity and evaluate the effects of drugs with distinct efficacies and potencies”, they say.
In today's world preserving old buildings is a widely debated topic. Some people believe that preserving them is essential for maintaining a connection to the past, while others argue that modern development should take priority over maintaining old structures. Both perspectives have valid points, and this essay will discuss both views before presenting a personal opinion.
4.The author’s true conclusion was identifying a specific G protein that activates phospholipase C, which is a key cellular regulator. This “PTX-insensitive G protein”, as the authors notes, “answers many of the questions about the regulation of this enzyme.” They conclude that the αq subunit represents “a subpopulation in the larger family of the trimeric G proteins,” unique in structure and role. Most importantly, they show that “the α subunit of Gq appears to be sufficient to effect stimulation,” acting alone to drive this physiological pathway.
Artificial intellegnce is being used commonly to drive cars.Time is running so fast,and it is the same for us.from that stage,I can say that we are all looking for things that turn our lives into something much easier than before.I insist it is a positive involvement in our lives,and there is no way to feel regret for once.
The Internet has greatly made our lives more convenient, in terms of our learning, entertainment, and daily life. We can use iPads for electronic teaching and take notes on them. In terms of entertainment, you can shoot short videos and play games in Tiktok. In daily life, online shopping can be done on Taobao and JD.com.
Some would argue that all students should take history as a main topic in their schools, while others would say that studying other subjects is essential for the youngsters in the present day.Although history is a very important subject to be studied in classes.I believe that a variety of subjects should be learned so that students gain a lot of knowledge and different world veiws.
In the last 20 years, the assessment of students has undergone major transformation. Many educational institutions no longer use formal examination as a means of assessment as they believe formal examination results are an unfair indication of a student’s ability. To what extent do you agree or disagree with this statement?
Nowadays, a new concept of colonialism has appeared, and it's called tourism. While it contributes to the destruction of the local business, it's also damaging the areas that have been used since colonialism. However, I personally don't agree with this opinion, since tourism refers to another term entirely of colonialism. While not mentioning that it can serve as a new source of income without forcing anyone to comes, as it's a good way to learn about different cultures. Whatever, I will examine the topic in details and prove my point
The mature physique is equally as important as the state of mind.In my opinion, they work both simultaneously in order the deliver great results. For example, when exercising it requires a powerful mind to help motivate the body to work harder. As a result of the spiritual capacity and body are as important
The line graph illustrates applyUK guests from overseas for different causes in 1989 and 2009. Overall, while two Trent shared similar standings in other one has various changes.
🚀 Prepare for IELTS writing section today!
  • Unlimited Task 1 & Task 2 checks
    Practice with essays, charts, and letters.
  • Personalized suggestions & mistake analysis
    Spot every mistake and boost your score.
  • Topic ideas & vocabulary helpers
    Expand your ideas and use the right words.
  • Progress tracking
    Watch your writing improve with every practice.