At 100nM, cisapride cut both the outward and tail currents in HERG cells (1A-1B). The control trace peaked near + 10 mV, bent slightly before the tail at - 50mV (1A), then fell once the drug was added. “Cisapride suppressed both currents,” the authors wrote. Control cells (1C) barely moved, and the current voltage plots (1D-1E) showed activation near -40mV with lower current after treatment. After that, as shown in Figure 2, the blocked came only after activation; the first pulse looked normal, with” little closed-state block,” but the current then fell during depolarization and almost returned after washout. Next, the dose data (3) gave an IC50 of 6.5nM. At different voltages, the last plot (4A-B) showed stronger block at higher voltage reaching almost 90% at +20 mV, linked to the open state of the channel.