Fig.1A-C show tirzepatide in open regions of the brain, notably the area postrema and NTS, both linked to appetite control. Then Fig. 2A-C point to activity in the NST, PBN and CeA, where GLP-1R and GIPR seem to act together there. Once GLP-1R is taken out of the brainstem (Fig. 3A-C), the effect fades, so these lower parts seem to drive the change. After that, Fig. 4A shows GIPR in red in the area postrema, close to GABA cells that quiet nearby GLP-1R neurons. Finally, in the later Figures (5-7), the CeA is clearer; these cells tie to feeding centers, and when silent, the shared effect drops away, so the CeA feels like the core of it all.