The study has a few limits. In their words, “our study recorded limited distribution after a single injection of fluorescently labelled TZP,” so the reach of the drug may differ with latter doses. Likewise, their scan of brain activity relied on single-dose data, which could have skewed the result. They add that methods used to study GIPR in the rodent brain don’t quite line up, and while the area postrema takes a central role, other sites may still play a part. It was hard too to pick out the NtsCeA cells from the many around them, and their role is still open to question.