IELTS Writing Samples Band 2.5

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Some individuals believe that to reduce crimes is to give longer prison sentences however others believe that, there are other alternatives. Here, I will discuss both the views and will give my own opinion to it.
Nobody can deny that government take play an important role in our life. The more modern of social life, the greater the responsibility of the state. Some people ague that parents have duty to bring their children to school, while others say that is the responsibility of the gorvernment. I myself agree with the second opinion which will be discuss in the following paragraph.
We can't deny that we are living in the age where most people value integration more than ever before. When countries do more business together and share more culture, some people think this is a good thing that helps everyone. However, other people worry that this globalization will make each country lose its special identity or unique way of life. This question bring about countless advantages and disadvantages, which will be discussed further as below.
Today almost everyone use computers but overusing technology and gadgets by children cause a big scale of concern. Unlimited acces to computers causes a various problems such mental and physical problems. Parental supervision and time limits seems logical in solving these problems.
Computers,Laptops and telephones has made everything accesible around us.After covid-19,people started working from home.I think working from has both advantages and disadvantages.Lets put light on the pros and cons of working from home.
There is no denying the fact that the internet has changed the world. It is a commonly held belief that the internet has made life easier. However, there is also an argument that it has created mnay problems. This essay will analyse both the advantages and disadvantages of the internet.
Environmental issues have been debated in recent years. While some people believe that the extinction of specific species of animals and plants is essential, others orgue that there are more important environmental issues.
In some countries, people appreciate celebrties like actors, famous football players, and social media bloggers way more than productive hard working individals like health care providers and teachers,
Some people argue that adults in charge of children should get punished,whilst I completely disagree with this statement, it's the child's responsibility and they should get hold accountable. This essay will discuss why children should get punished for their own actions.
The debat of adaptation or improving conditions has gained attention in recent years. While some people believe that it is better to accept a truble condition like job issues, others argue that it is better to attempt to change bad conditions.
Focusing on the current is more vital While, some oppose this notion, I personally argue in favor as there is no a lot of stress.
The pie charts compare parents' happiness percentage based on the age of their children.
The topic of whether the young old should begin their education at a very early age, or others say they should start school later, has become a subject of debate. Many people believe that children should begin their formal education at a very early age, while
In this paper, the authors test whether an allosteric drug, with a catalytic-site tyrosine kinase inhibitor (TKI) can control chronic myeloid leukaemia (CML) better than one drug on its own. To do this, ABL001 binds in the myristoyl pocket of BCR-ABL1 and turns the kinase off. Nilotinib sits in the catalytic site. Each drug misses a different set of BCR-ABL1 mutants, so one drug alone can still leave a small group of cells that still grow. So in mouse CML xenografts, the two drugs together shrank tumours, and they didn’t grow back after treatment stopped. The ABL001-nilotinib pair left little room for resistance in this setting.
4.The authors see ABL001 as a way to test “dual inhibition of BCR-ABL1 using distinct targeting mechanisms”, with tighter control of BCR-ABL1 and less room for resistance as the aim. Form their cell and mouse work they pick out “non-overlapping resistance profiles” for myristoyl site and catalytic site drugs, and they take the view that a pair of them can work as a higher barrier than either drug alone. With support from simple modeling and early phase I signals, they finish by saying that once safe doses are known, ABL001 plus a TKI should be tested to achieve treatment-free remission in patients with CML”.
This idea hinges mainly on work in Figures 2,3 and 4. In barcoded KCL-22 cells (Figure 2b-f), clones that grow with ABL001 are not the ones that grow with nilotinib, so each drug leaves a different resistance pool. KCL-22 xenografts on single-agent ABL001 or nilotinib show an early drop in tumor size and then a return of growth with resistance (Figure 3a). With the ABL001-nilotinib pair from the start (Figure 3b), tumor size falls and does not return after treatment stops. In one CML patient, ABL001 gives a clear response and later the disease comes back with myristoyl-pocket mutations, the same kind of resistance as in the preclinical work (Figure 4).
2.The authors test this idea in a few linked ways. They first show how ABL001 works as an allosteric inhibitor with crystal structures, NMR, and tests of ABL1 activity and cell growth in BCR-ABL1- dependent cells. They then track resistance with a barcoded KCL-22 population treated with ABL001 or nilotinib, to see which pre-existing clones grow out under each drug. Next, they treat mouse CML xenografts with ABL001 or nilotinib alone and with ABL001-nilotinib pair and follow tumour shrinkage and relapse after treatment stops. They also look at early phase I data for ABL001 in patients with CML to confirm that the drug has clinical activity and to flag resistance in humans.
1.In this paper, the authors test whether an allosteric drug, with a catalytic-site tyrosine kinase inhibitor (TKI) can control chronic myeloid leukemia (CML) better than one drug on its own. ABL001 binds in the myristoyl pocket of BCR-ABL1 and turns the kinase off. Nilotinib sits in the catalytic site. Each drug misses a different set of BCR-ABL1 mutants, so one drug alone can still leave small group of cells that still grow. In mouse CML xenografts, the two drugs together shrank tumours, and they didn’t grow back after treatment stopped. The ABL001-nilotinib pair left little room for resistance in this setting.
There is ongoing debate as watching TV has negative impact for children's health and behaviur. Others think, however, that TV is helpful for their education and entertainment. This essay will discuss both views and give my own opinion.
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