IELTS Writing Samples Band 2.5

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The pie charts compare parents' happiness percentage based on the age of their children.
The topic of whether the young old should begin their education at a very early age, or others say they should start school later, has become a subject of debate. Many people believe that children should begin their formal education at a very early age, while
In this paper, the authors test whether an allosteric drug, with a catalytic-site tyrosine kinase inhibitor (TKI) can control chronic myeloid leukaemia (CML) better than one drug on its own. To do this, ABL001 binds in the myristoyl pocket of BCR-ABL1 and turns the kinase off. Nilotinib sits in the catalytic site. Each drug misses a different set of BCR-ABL1 mutants, so one drug alone can still leave a small group of cells that still grow. So in mouse CML xenografts, the two drugs together shrank tumours, and they didn’t grow back after treatment stopped. The ABL001-nilotinib pair left little room for resistance in this setting.
4.The authors see ABL001 as a way to test “dual inhibition of BCR-ABL1 using distinct targeting mechanisms”, with tighter control of BCR-ABL1 and less room for resistance as the aim. Form their cell and mouse work they pick out “non-overlapping resistance profiles” for myristoyl site and catalytic site drugs, and they take the view that a pair of them can work as a higher barrier than either drug alone. With support from simple modeling and early phase I signals, they finish by saying that once safe doses are known, ABL001 plus a TKI should be tested to achieve treatment-free remission in patients with CML”.
This idea hinges mainly on work in Figures 2,3 and 4. In barcoded KCL-22 cells (Figure 2b-f), clones that grow with ABL001 are not the ones that grow with nilotinib, so each drug leaves a different resistance pool. KCL-22 xenografts on single-agent ABL001 or nilotinib show an early drop in tumor size and then a return of growth with resistance (Figure 3a). With the ABL001-nilotinib pair from the start (Figure 3b), tumor size falls and does not return after treatment stops. In one CML patient, ABL001 gives a clear response and later the disease comes back with myristoyl-pocket mutations, the same kind of resistance as in the preclinical work (Figure 4).
2.The authors test this idea in a few linked ways. They first show how ABL001 works as an allosteric inhibitor with crystal structures, NMR, and tests of ABL1 activity and cell growth in BCR-ABL1- dependent cells. They then track resistance with a barcoded KCL-22 population treated with ABL001 or nilotinib, to see which pre-existing clones grow out under each drug. Next, they treat mouse CML xenografts with ABL001 or nilotinib alone and with ABL001-nilotinib pair and follow tumour shrinkage and relapse after treatment stops. They also look at early phase I data for ABL001 in patients with CML to confirm that the drug has clinical activity and to flag resistance in humans.
1.In this paper, the authors test whether an allosteric drug, with a catalytic-site tyrosine kinase inhibitor (TKI) can control chronic myeloid leukemia (CML) better than one drug on its own. ABL001 binds in the myristoyl pocket of BCR-ABL1 and turns the kinase off. Nilotinib sits in the catalytic site. Each drug misses a different set of BCR-ABL1 mutants, so one drug alone can still leave small group of cells that still grow. In mouse CML xenografts, the two drugs together shrank tumours, and they didn’t grow back after treatment stopped. The ABL001-nilotinib pair left little room for resistance in this setting.
There is ongoing debate as watching TV has negative impact for children's health and behaviur. Others think, however, that TV is helpful for their education and entertainment. This essay will discuss both views and give my own opinion.
In most countries, participants are choosing to live independently instead of living with their families. I think this is a negative development, although some people see it as a positive development.
The persistence of hunger despite these agricultural advances has become a global concern. There are several reasons why this is happening.
It is a pie chat that shows the percentage of the reasons why people leave or stay in UK.
Some individuals prefer to do same stuff without any changes , other people qre concerned about how beneficial difference is . This essay will discuss both of these views , frequency of changes can damage convinience and how essential it is for career growth .
goverments and big organizations must started working with each other to help the enviorment from beging damaged, rather than waiting got residance to take the responsibility. i strongley agree that organzations and the goverment should look out for there degital footprints and review what they can do better to the planet.
For somes countries that perfect enjoying life than earning money, owining a house is more significant than renting one. Buying a house cost more money in short time, while it is more stable in a long term. When it comes to the reasons, the social ideas and financial development matters.
The debate of allowing children to make their own choices on daily matters has gained attention in recent years. While some people believe that children's decision-making, can build a narcissistic society, others argue that these topics are impactful on their character.
The debait of allowing children to make thier own choises on dialy matters has gained attention in recent years. While some people believe that children decision-making, can build narcissistic society, other argue that this topics are impacable on thier carecter.
In my opinion, online shops can replace some stores, but also can make life easier. Some people actually like walking by shops and looking at clothes, products and items by themselves, but it can cause some difficulties. I mean, in real shops you can have problems like queues, people, which can obstruct you from shopping. Especially, if you don’t have too much time.
Some people think art such as sculpture and music cannot improve the quality of people's lives so the government should not spend money on them, such thinking is not necessarily accurate. We have seen examples of monuments that have become the identity of the cities they are in and they have created massive economic activity around it.
There are a few young individuals who consider to study in school is challenging and therefore quit schooling in their early years and remain academically unqualified. This issue might be caused by generalised curriculam for students. However, it can be reduced by taking a number of efficient strategies for example private care and incentives in specialised programmes.
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