For a prescribing veterinarian, Sileo is an α2-adrenergic agonist that doesn’t sedate so much as softly quiets the storm in an anxious dog. The Oro mucosal gel allows rapid absorption through the gum, bypassing the need for injection or tablets, and delivers calm within minutes. In clinical trials, nearly three-quarters of owners observed a good or excellent effect, compared with only a third in the placebo group, a genuine reflection of its reliability during stressful firework events. What makes Sileo distinctive is how it soothes without stripping awareness, most dogs stay responsive, able to walk, eat, or make eye contact, but without the tremors or frantic pacing. Side effects, when they appear, are mild and transient, a touch of drooling, momentary drowsiness, or a little less alertness than usual.