Avicennia marine, locally known as Api-api putih in Indonesia, is one of the mangrove species that belongs to the Avicenniacea family and can be found in Africa, Asia, Australia, New Zealand, Polynesia, and South America. It is one of the mangrove trees which every part of the plant traditionally can be utilized to support the local community’s daily life. This continuously has been raising a great deal of interest to explore the bioactive compounds contained in Avicennia marina. In the past years, several studies revealed that bioactive compounds contained in Avicennia marina have numerous bioactivities such as antibacterial, antivirus, antifungal, and antioxidant. Therefore, due to the wide variety of biaoactive compounds contained in Avicennia marina and its promising potential utilization, it is necessary to determine the preparation method to obtain optimal bioactive components.