Africa is facing various educational challenges due to limited infrastructure, resources, and a shortage of qualified teachers. Artificial Intelligence in E-learning is applied over the world as a breakthrough technological tool, offering personalized learning and the ability to approach which help address the educational inequality in Africa. However, using AI is only effective if deployed with the consideration of infrastructure, cultural context, and sustainable funding. Despite its challenges, AI holds the potential to support cross-border education in Africa by optimizing resources and reaching remote areas.