Several different interventions have been developed over the years to treat epilepsy. Most epileptic patients receive anti-epileptic drugs (AED), now known as anti-seizure drugs (ASD), as their first line of defense to suppress seizures and regain their quality of life. Among the mechanisms by which ASDs reduce seizures are regulating ion channels, inhibiting glutamate-mediated neurotransmitter interactions, and enhancing the inhibition of GABA transmission. About one-third of epileptic patients are often resistant to anti-convulsant drugs, while others develop numerous side effects, which may lead to treatment discontinuation and further deterioration of quality of life. Common side effects of ASDs include headaches, nausea, and dizziness. However, more adverse effects, such as auditory and visual problems, skin problems, liver dysfunction, pancreatitis, and kidney disorders may also be observed. Some ASDs may even result in life-threatening conditions as well as serious abnormalit...