Nowadays, Monkeypox has a mortality rate that varies from 0.1 to 10%, and many people are wondering if it will lead to a pandemic like COVID-19 or not? Despite people's fear of the Mpox disease, it will not lead to a panademic as it has a different way of transmission (Maria Cheng,2024). Although there are some similarities between both viruses, but still, the differences are noticeable in the method of transmission, their nucleic acid and their symptoms. In this essay, I will discuss each point for both viruses.